[Vitamin D concentration in type 1 diabetic children. Association with glycemic control, lipidic and bone metabolism]. / Concentración de vitamina D en niños diabéticos de tipo 1. Asociación con el control glucémico y el metabolismo óseo y lipídico.

Introduction: Introduction: vitamin D plays a key role in regulating insulin secretion and its deficit seems to confer an increased risk of developing diabetes mellitus. In this study, we have tried to analyze the prevalence of vitamin D deficiency in our type 1 diabetic children population and if their deficiency is related to a worse control of the disease, as well as with their bone and lipid metabolism. Material and methods: this is a retrospective study, in which both clinical and laboratory data were available for 124 children who were controlled in the Pediatric Diabetes Unit of our Hospital. Results: the median vitamin D concentration of the total sample was 25.41 (7.43) ng/ml, higher in males than in females (p = 0.006); 43.55 % of patients had good metabolic control with glycosylated hemoglobin lower than 7.5 %. Slightly lower glucose and cholesterol concentrations and higher bone alkaline phosphatase concentrations were found when vitamin D concentration was ≥ 20 ng/ml. Conclusions: we have not found any significant differences in relation to metabolic control between children with sufficient and insufficient concentration of vitamin D. The children in the present study presented very similar vitamin D concentrations to those found in a study made in healthy children, and a good metabolic control of their diabetes, with bone and lipid profiles being more favorable when they had good metabolic control.

Introducción: Introducción: debido a que la vitamina D juega un papel primordial en la regulación de la secreción de insulina y su déficit parece conferir un mayor riesgo de desarrollar diabetes mellitus, se ha pretendido analizar la prevalencia del déficit de vitamina D en nuestra población de niños diabéticos de tipo 1 y si se relaciona con un peor control de la enfermedad, así como con el metabolismo lipídico y óseo. Material y métodos: se trata de un estudio retrospectivo en el cual se disponía de los datos clínicos y analíticos de 124 niños diabéticos de tipo 1, controlados en la Unidad de Diabetes Pediátrica de nuestro hospital. Resultados: la concentración mediana de vitamina D del total de la muestra fue de 25,41 (7,43) ng/mL, siendo más elevada en el sexo masculino que en el femenino (p = 0,006). Un 43,55 % de los niños presentaron buen control metabólico, con hemoglobina glicosilada inferior al 7,5 %, siendo la concentración de glucosa y la de colesterol ligeramente más bajas, y la de fosfatasa alcalina ósea más elevada cuando la concentración de vitamina D era ≥ 20 ng/ml. Conclusiones: no hemos encontrado diferencias significativas en el control metabólico de los niños con concentración suficiente o insuficiente de vitamina D. Los niños del estudio tenían concentraciones de vitamina D muy parecidas a las de un estudio similar en niños sanos, así como un buen control metabólico de su diabetes, siendo su perfil óseo y lipídico más favorable cuando presentaban buen control metabólico.

Concentración de vitamina D en niños diabéticos de tipo 1. Asociación con el control glucémico y el metabolismo óseo y lipídico / Vitamin D concentration in type 1 diabetic children. Association with glycemic control, lipidic and bone metabolism

Introducción: debido a que la vitamina D juega un papel primordial en la regulación de la secreción de insulina y su déficit parece conferir un mayor riesgo de desarrollar diabetes mellitus, se ha pretendido analizar la prevalencia del déficit de vitamina D en nuestra población de niños diabéticos de tipo 1 y si se relaciona con un peor control de la enfermedad, así como con el metabolismo lipídico y óseo. Material y métodos: se trata de un estudio retrospectivo en el cual se disponía de los datos clínicos y analíticos de 124 niños diabéticos de tipo 1, controlados en la Unidad de Diabetes Pediátrica de nuestro hospital. Resultados: la concentración mediana de vitamina D del total de la muestra fue de 25,41 (7,43) ng/mL, siendo más elevada en el sexo masculino que en el femenino (p = 0,006). Un 43,55 % de los niños presentaron buen control metabólico, con hemoglobina glicosilada inferior al 7,5 %, siendo la concentración de glucosa y la de colesterol ligeramente más bajas, y la de fosfatasa alcalina ósea más elevada, cuando la concentración de vitamina D era ≥ 20 ng/ml. Conclusiones: no hemos encontrado diferencias significativas en el control metabólico de los niños con concentración suficiente o insuficiente de vitamina D. Los niños del estudio tenían concentraciones de vitamina D muy parecidas a las de un estudio similar en niños sanos, así como un buen control metabólico de su diabetes, siendo su perfil óseo y lipídico más favorable cuando presentaban buen control metabólico. (AU)

Introduction: vitamin D plays a key role in regulating insulin secretion and its deficit seems to confer an increased risk of developing diabetes mellitus. In this study, we have tried to analyze the prevalence of vitamin D deficiency in our type 1 diabetic children population and if their deficiency is related to a worse control of the disease, as well as with their bone and lipid metabolism. Material and methods: this is a retrospective study, in which both clinical and laboratory data were available for 124 children, who were controlled in the Pediatric Diabetes Unit of our Hospital. Results: the median vitamin D concentration of the total sample was 25.41 (7.43) ng/ml, higher in males than in females (p = 0.006); 43.55 % of patients had good metabolic control, with glycosylated hemoglobin lower than 7.5 %. Slightly lower glucose and cholesterol concentrations and higher bone alkaline phosphatase concentrations were found, when vitamin D concentration was ≥ 20 ng/ml. Conclusions: we have not found any significant differences in relation to metabolic control between children with sufficient and insufficient concentration of vitamin D. The children in the present study presented very similar vitamin D concentrations to those found in a study made in healthy children, and a good metabolic control of their diabetes, with bone and lipid profiles being more favorable when they had good metabolic control. (AU)

Impact on the well-being perceived by caregivers of children and adolescents with type 1 diabetes following the use of interstitial glucose measurement systems.

INTRODUCTION: Type 1 diabetes mellitus (DM-1) is one of the most common chronic childhood diseases, and it is essential to optimize glycemic control in order to avoid complications. For years, interstitial glucose measurement systems (MGI systems) have been among the new technologies at the forefront of self-care. OBJECTIVES: To determine the impact on the well-being of the caregivers of patients with DM-1 under 18 years of age, controlled at a Pediatric Diabetes Unit of a third level hospital, of the use of MGI systems. MATERIAL AND METHODS: This was an observational, descriptive and analytical cohort study based on a questionnaire completed by the patients' caregivers, as well as from the patient's clinical history. RESULTS: There were 120 participants (55.5% males), with a mean age 13.20 +/- 3.71 years and mean glycosylated haemoglobin (HbA1c) 7.36% +/- 0.90. 52.5% of the sample used MGI systems. The caregivers of patients using MGI systems showed significantly higher scores (p < 0.05) regarding well-being, compared to the caregivers of patients not using this technology. In the former, a significant improvement (p < 0.05) in these variables with respect to the values prior to the beginning of their use was observed. CONCLUSIONS: The use of MGI systems for diabetes self-management in our study led to a greater sense of well-being on the part of caregivers compared with before their introduction, as well as in comparison with those who continued to perform measurements using daily capillary glycemias.

Impact on the well-being perceived by caregivers of children and adolescents with type 1 diabetes following the use of interstitial glucose measurement systems. / Impacto en el bienestar percibido por cuidadores de niños y adolescentes con diabetes tipo 1 mediante la utilización de sistemas de medición de glucosa intersticial.

INTRODUCTION: Type 1 diabetes mellitus (DM-1) is one of the most common chronic childhood diseases, and it is essential to optimize glycemic control in order to avoid complications. For years, interstitial glucose measurement systems (MGI systems) have been among the new technologies at the forefront of self-care. OBJECTIVES: To determine the impact on the well-being of the caregivers of patients with type 1 diabetes mellitus under 18 years of age, controlled at a Pediatric Diabetes Unit of a third level hospital, of the use of MGI systems. MATERIAL AND METHODS: This was an observational, descriptive and analytical cohort study based on a questionnaire completed by the patients' caregivers, as well as from the patient's clinical history. RESULTS: There were 120 participants (55.5% males), with a mean age 13.20+/-3.71 years and mean glycosylated haemoglobin (HbA1c) 7.36%+/-0.90. 52.5% of the sample used MGI systems. The caregivers of patients using MGI systems showed significantly higher scores (p<.05) regarding well-being, compared to the caregivers of patients not using this technology. In the former, a significant improvement (p<.05) in these variables with respect to the values prior to the beginning of their use was observed. CONCLUSIONS: The use of MGI systems for diabetes self-management in our study led to a greater sense of well-being on the part of caregivers compared with before their introduction, as well as in comparison with those who continued to perform measurements using daily capillary glycemias.

Diabetes tipo MODY-3, no todo debut es diabetes tipo 1 / MODY 3 diabetes, not every early onset diabetes is type 1 diabetes

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